Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants

NIAID Data Ecosystem2026-03-12 收录

神经干细胞致癌性

组蛋白突变表观遗传学

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Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants

创建时间：

2021-09-09

Histone H3-G34V and H3-G34R mutant fission yeast exhibit distinct chromatin changes and different DNA damage sensitivities.

组蛋白突变表观遗传学

DNA损伤修复机制

Recurrent somatic mutations of H3F3A in aggressive pediatric high-grade gliomas generate K27M or G34R mutant histone H3.3. H3.3-G34R mutants are common in tumors additionally mutant for p53 and ATRX,

NIAID Data Ecosystem40

Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects

弥漫性内生性脑桥胶质瘤（DIPG）机制研究

组蛋白突变表观遗传学

A mouse knock-in model engineered for Cre recombinase-activated expression of the endogenous mouse H3f3a allele generating an epitope-tagged H3.3 equipped with or without a K27M mutation to investigat

NIAID Data Ecosystem20

The histone H3G34R mutation disrupts the epigenome via catalytic inactivation of the ASH1 H3K36 methyltransferase. The histone H3G34R mutation disrupts the epigenome via catalytic inactivation of the ASH1 H3K36 methyltransferase

组蛋白突变表观遗传学

H3K36甲基化

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem10

Spontaneous DIPG Modeling Reveals Novel H3.3 K27M-Mediated Oncogenic Mechanisms Acting Through Epigenetic Effects

弥漫内生性脑桥胶质瘤致癌机制

组蛋白突变表观遗传学

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem40

DNA replication profiling by BrdU Immunoprecipitation of S.cerevisiae wild-type versus H3K37R mutant. DNA replication profiling by BrdU Immunoprecipitation of S.cerevisiae wild-type versus H3K37R mutant

DNA复制分析

组蛋白突变表观遗传学

Wild-type and isogenic H3K37R yeast cultures were sinchronized in G1 with alpha factor. Cell were released into the cycle in the presence of 200mM Hydroxyurea and 0.5mg/ml BrdU. After 1h 15 minutes at

NIAID Data Ecosystem10

Regional identity of human neural stem cells determinesoncogenic responses to histone 1H3.3 mutants

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