Known diagnostic protein biomarkers were significantly enriched in the sets of differentially expressed RNA for 22 out of 41 diseases.

*Number of genes that were differentially expressed in any one of the disease tissues at the mRNA level (fpf≤0.05, RankProd R package) with detectable protein abundance in the biofluid proteome database (see Methods). *Number of known diagnostic protein biomarkers in clinical and preclinical studies from the GVK BIO Online Biomarker Database (GOBIOM). **Number of correctly predicted diagnostic protein biomarkers. $P values were calculated to evaluate whether known protein biomarkers were significantly enriched in our predicted genes using Fisher's exact test.