A Convergent Synthesis of the Fully Elaborated Macrocyclic Core of TMC-95A
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A concise and straightforward synthesis of the fully elaborated macrocyclic core of TMC-95A is reported. A highly efficient organocatalyzed aldolization between isatin and dihydroxyacetone derivatives and formation of the biaryl subunit with concomitant macrocyclization are the characteristic features of this synthesis.
创建时间：
2016-02-18
