Clinically important adverse events and intolerable adverse events leading to treatment failure.

aClinicians judged whether the adverse events recorded in the medical diaries of the patients were clinically important.bIAEs = Intolerable adverse events leading to treatment failure. The patients who discontinued study AEDs due to lack of efficacy combined with intolerable adverse events were also included in this column.cDenoted the total number of patients with at least one clinically important adverse event or intolerable adverse event.dExtrapyramidal symptoms included tremor and abnormal gait.eGastrointestinal reactions included nausea, vomiting and abdominal discomfort.fHaematological system abnormalities included thrombocytopoenia, leucopoenia, and anaemia.