Small Intestinal And Faecal Microbiota Of Adult Celiac Patients And First-Degree Relatives.. human gut metagenome

Celiac disease (CeD) is an autoimmune disease characterized by the hypersensitive reaction to gluten in the small intestine of genetically susceptible individuals. Approximately 1% of the world population is affected by CeD. Recently, the potential role of intestinal microbiota as a contributing factor to development of CeD has been hypothesized. While most of the research is focused on paediatric subjects, understating of changes in adult intestinal microbiota before and during active disease is lacking, also the studies with microbiome profile of faecal as well as biopsy samples are limited. Here we have made an attempt to unravel the possible role of gut microbiota in celiac disease