Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia
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https://www.ncbi.nlm.nih.gov/sra/ERP121779
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资源简介：
Our study illustrates the leukemic role of deregulated NKL homeobox genes HMX2 and HMX3 revealing molecular mechanisms of differentiation arrest in AML.Whole genome sequencing of EOL-1 identified two mutations in the regulatory upstream regions of HMX2/3 resulting in the generation of a novel ETS-site and transformation of a former NFkB-site into an SP1-site.
创建时间：
2023-10-13
