The human monocyte model BLaER1 exhibits an epigenetic GPI anchor defect that impairs TLR4 signaling
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE169623
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We show that the human monocyte model BLaER1 contains GPI-anchor-deficient cells, which lack CD14 surface expression when differentiated to monocytes, resulting in diminished LPS/TLR4 responsiveness. We found that this GPI anchor defect is caused by epigenetic silencing of the PIGH gene, leading to a random distribution of intact and PIGH-deficient clones after single-cell cloning. Comparison of mRNA expression profiles of 3 undifferentiated GPI-positive and 4 undifferentiated GPI-negative BLaER1 monoclonal cell lines
创建时间：
2021-07-28
