Effect of disruption of STAT3 Y705 phosphorylation on lung gene expression in mice during influenza virus infection

To investigate the functional relevance of the STAT3 Y705 in antiviral immunity, we established STAT3 705 tyrosine site mutation (STAT3Y705F/+) mice and infected them with influenza virus for 24 h, then collected the lungs. We then performed gene expression profiling analysis using data obtained from RNA-seq of 3 different samples. Overall design: Comparative gene expression profiling analysis of RNA-seq data for lungs of in WSN-infected WT mice and STAT3Y705F/+ mice.