Inherited blood cancer predisposition through altered transcription elongation [single-cell RNA-seq]
收藏NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE186590
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We identified CTR9 mutants as rare heritible contributing factors to several blood cancers. We later identified partial loss of CTR9 is capable of driving key hematopoietic maintenance and self-renewal gene expression through altered transcription elongation. CD34+ HSPCs edited by AAVS1, CTR9 guide RNAs were subject to single cell RNA-seq analysis
创建时间：
2024-01-16
