Properties of the murine anti-fHbp mAbs.
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All but one of the hybridomas were from CD-1 mice. The exception, JAR 65, was from a human fH transgenic BALB/c mouse [43].*fHbp mutants with amino acid substitutions at these positions lost (knocked-out) or gained (knocked-in) mAb binding [32], [39].**The amide signals of Gly148, Arg149, and Ala174 showed chemical shifts by NMR upon binding with fHbp [29].
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2015-12-02
