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A context-specific cardiac Beta-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

NIAID Data Ecosystem2026-03-14 收录

心脏疾病分子机制

转录因子调控网络

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE97763 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2023-02-08

细胞分化机制

转录因子调控网络

EBF1 is essential for B cell specification and commitment. To explore the dynamics of EBF1 initiated B cell programming, we performed EBF1 ChIP-seq, ATAC-seq, bisulfite-seq, RNA-seq and several histon

NIAID Data Ecosystem30

AP-1 Imprints a Reversible Transcriptional Programme of Senescent Cells. AP-1 Imprints a Reversible Transcriptional Programme of Senescent Cells

早衰症表观遗传学

转录因子调控网络

Senescent cells affect many physiological and pathophysiological processes. While select genetic and epigenetic elements for senescence induction have been identified, the dynamics, epigenetic mechani

NIAID Data Ecosystem20

Crossroads of the p53, ER, NFkB stress response networks

转录因子调控网络

乳腺癌应激响应

We explored the combinatorial interactions between p53, estrogen receptors and NFkB using the breast adenocarcinoma-derived MCF7 cells. Recently, we have established that p53 can modulate transcriptio

NIAID Data Ecosystem10

Sox10 Controls Migration of B16F10 Melanoma Cells through Multiple Regulatory Target Genes

黑色素瘤转移

转录因子调控网络

It is believed that the inherent differentiation program of melanocytes during embryogenesis predisposes melanoma cells to high frequency of metastasis. Sox10, a transcription factor expressed in neur

Figshare2016-01-18 更新30

Analysis of m6A methylome in CHAPIR overexpressed heart [MeRIP]

RNA表观遗传学

心脏疾病分子机制

To elucidate the molecular mechanism by which cardiac-hypertrophy-associated piRNA (CHAPIR) regulates m6A modification, we performed m6A methylated RNA immunoprecipitation sequencing (MeRIP-seq) in co

NIAID Data Ecosystem20

A context-specific cardiac Beta-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart

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