Data repository for StructureDCA Data repository for the publication:Matsvei Tsishyn, Hugo Talibart, Marianne Rooman, Fabrizio Pucci. Structure-informed direct coupling analysis improves protein muta
Accurately identifying the missense mutations is of great help to alleviate the loss of protein function and structural changes, which might greatly reduce the risk of disease for tumor suppressor gen
本数据集为May等人相关研究的汇总数据,包含基于错义变异稳定性破坏估计的全基因组功能约束指标,用于分析功能受限人类蛋白质对单氨基酸替换突变稳定性的敏感性差异,共含一份文件。 May等人研究论文"Functionally constrained human proteins are less prone to mutational instability from single amino acid