LINE-1 elements are derepressed in senescent cells and elicit a chronic Type-I Interferon response
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
It is not known to what extent retrotransposable elements contribute to the development of age-associated diseases. Here we show that during cellular senescence L1s become transcriptionally derepressed and trigger a type-I interferon (IFN-1) response. We propose that RTE activation is an important component of the sterile inflammation that is a hallmark of aging, and that L1 reverse transcriptase is a relevant target for the development of drugs to treat associated disorders.
提供机构：
Brown University
创建时间：
2022-02-20
