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Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE117248
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We report the generation of isogenic hPSC model of FXS and characterize the neurodevelopmental capacity of these cells, performed transcriptome profiling in FXS neurons and identified key pathways Transcriptome profiling of FXS-derived neurons from hESC generated by RNA-seq in four replicates per genotype for using Illumina HiSeq4000. Control and FXS-derived neurons from hiPSC were generated by RNA-seq in 3 replicates per genotype.
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2020-09-08
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