Impact of ALK inhibition or phospho-deficient mutation of CDK9 on gene expression in ovarian cancer cells

The goal of this study is to determine the impact of ALK inhibition or phospho-deficient mutation of CDK9 on gene expresion profiles in ovarian cancer cells Overall design: We performed bulk RNA sequencing on three cellular phenotypes: (1) cells expressing WT CDK9, (2) cells expressing WT CDK9 treated with an ALK inhibitor, and (3) cells expressing Y19F-mutant (phospho-deficient) CDK9