Single-cell transcriptome analysis of Myt1l mutant mouse cortices at birth.. Single-cell transcriptome analysis of Myt1l mutant mouse cortices at birth.

We examined the effect of Myt1l deficiency in the cortices of mice at birth on the single cell level. Homozygous Myt1l deficiency resulted in postnatal lethality, and mutant mice presented increased expression of non-neuronal genes in neurons. Overall design: Single-cell RNA sequencing of Myt1l (+/+; WT), Myt1l (+/-; HET), and Myt1l (-/-; HOM) mouse cortices at birth.