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Resolution of R-Loops by topoisomerase III-B (TOP3B) in coordination with the DEAD-box helicase DDX5. Saha et al.

Name: Resolution of R-Loops by topoisomerase III-B (TOP3B) in coordination with the DEAD-box helicase DDX5. Saha et al.
Creator: Sourav Saha
Published: 2026-04-09T12:26:12+08:00

Mendeley Data2026-04-09 收录

R-loop解析机制

TOP3B-DDX5协同作用

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Raw data related to article "Resolution of R-Loops by topoisomerase III-B (TOP3B) in coordination with the DEAD-box helicase DDX5"

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Sourav Saha

转录-复制冲突

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Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant cancers, we sought t

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A non-canonical R-loop resolving function of PIWIL4 maintains the genomic integrity and leukemic growth of AML cells [PAR-CLIP]

R-loop解析机制

急性髓系白血病

PIWIL4 is a RNA binding enzyme required for the resolution of R-loops in AML cells. We examine the RNA associated with PIWIL4 protein in AML cell line THP-1 Examination of PIWIL4 protein associated RN

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CUT&Tag analysis of R-loops in Ube2t knockdown P19 cells (optimized). CUT&Tag analysis of R-loops in Ube2t knockdown P19 cells (optimized)

R-loop解析机制

表观遗传调控

DNA sequencing of libraries from CUT&Tag with R-loops antibody (S9.6) in Ube2t knockdown and control P19 cells Overall design: To understand the role of UBE2T in resolving R-loops. Mouse P19 cells wer

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The PARP1-EXD2 Axis Orchestrates R-Loop Resolution to Safeguard Genome Stability

R-loop解析机制

基因组稳定性

R-loops represent three-stranded nucleic acid structures comprising an RNA-DNA hybrid and a displaced single-stranded DNA. Deregulation of R-loop dynamics can obstruct DNA transcription and replicatio

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Resolution of R-Loops by topoisomerase III-B (TOP3B) in coordination with the DEAD-box helicase DDX5. Saha et al.

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