Supporting data for “The role of IL-25 in the development of murine lupus”

This research focused on exploring the role of IL-25 in the pathogenesis of SLE and potential therapeutic strategies for treating SLE. SLE is an autoimmune disease characterized by autoantibody production and systemic chronic inflammation. This study showed that IL-25 can alleviate lupus development by suppressing Th17 differentiation and glycolysis, which indicates the therapeutic effect of IL-25 in treating lupus. A well-established lupus mouse model was used to mimic the disease phenotypes of human SLE and the underlying molecular mechanism was investigated. C57 mice, IL-25 KO mice, IL-17RB KO mice, and NSG mice were used for lupus induction. Murine samples including serum, spleen, lymph nodes, kidneys, thymus, and bone marrow, as well as human samples including serum and PBMCs, were used during the project. My data files are related to chapters 3 to 7 in my thesis. In order to upload the data successfully, the chapters were separated into several sub-chapters, such as chapter 3-1 and chapter 3-2.

本研究聚焦于探讨IL-25在系统性红斑狼疮（SLE）发病机制中的作用及其潜在的治疗策略。系统性红斑狼疮是一种以自身抗体产生和系统性慢性炎症为特征的自身免疫性疾病。研究结果表明，IL-25可通过抑制Th17分化和糖酵解来缓解狼疮的发展，这表明IL-25在治疗狼疮中具有潜在的疗效。本研究采用成熟的狼疮小鼠模型来模拟人类SLE的疾病表型和潜在的分子机制。实验中使用了C57小鼠、IL-25敲除小鼠、IL-17RB敲除小鼠和NSG小鼠以诱导狼疮。在项目过程中，使用了包括血清、脾脏、淋巴结、肾脏、胸腺和骨髓在内的鼠类样本，以及包括血清和PBMCs在内的人类样本。我的数据文件与论文中的第3章至第7章相关。为了成功上传数据，相关章节被分割为多个子章节，如第3章-1和第3章-2。