MAPK/ERK signaling and metabolic deregulation by immunohistochemistry.

1(+) Increased (or equivalent) staining relative to normal mucosa (−) decreased staining.2Nonuniform staining throughout the tumors.3pMEK1&2 is significantly upregulated in all tumors relative to normal mucosa, Fisher exact P4p42p44MAPK is significantly upregulated in all tumors relative to normal mucosa, Fisher exact P5p42p44MAPK significantly upregulated in adenocarcinomas of the small intestine relative to adenomas of the colon, Fisher exact P6pS6K is upregulated (nonuniform staining) in all tumors relative to normal mucosa, Fisher exact P7PDPK1 is upregulated in all tumors relative to normal mucosa, Fisher exact P8pPDPK1 is significantly upregulated and membrane associated in all tumors relative to normal mucosa, Fisher exact P