LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 15 of 15: Calculated dose-response metrics.

To generate measures of the sensitivities of six cell lines to a library of small molecule inhibitors, we treated cells with single drugs at six doses starting at 10 µM in 3x dilution steps and measured cell number after three days of drug exposure. This dataset presents the dose-response metrics (GR_AOC) calculated using the normalized growth rate inhibition values reported in HMS LINCS Datasets #20245-20251. As part of this LINCS Pilot Phase Joint Project, L1000 gene expression data generated by the Broad LINCS Center for the same set of cells and perturbagens is available at http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE70138.