HIV TAT-interacting protein 2 (HTATIP2) in T cell regulation and type 1 diabetes

We completed the first genome-wide association study of the age at diagnosis of type 1 diabetes as a quantitative trait. Our analysis found a locus on chromosome 11 containing the SNP rs10833518. Functional studies implicate HTATIP2 as the causal gene for this association. The data in this project are RNA-seq results from primary human CD4+ T cells transfected with non-targeting siRNA as a control or with siRNA SMARTpool targeting HTATIP2.