Stimulation of TRPV1+ sensory nerves at nape induces significant alterations in gene expression in the spleen

RNA-seq analysis was performed to characterize the transcriptional changes in the spleen triggered by distinct treatments. Capsaicin (CAP) treatment not only induced anti-inflammatory effects in inflamed states but also inhibited the immune response under normal physiological conditions. Overall design: RNA-seq analysis was performed to characterize the transcriptional changes in the spleen triggered by distinct treatments, including saline control, CAP alone, LPS alone or CAP-LPS treatment.