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Chromatin accessibilty profiling of SCA1+ and SCA1- lineage traced VSMCs

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP469457
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VSMCs expressing SCA1 have increased proliferative capacity (Dobnikar et al, 2018; Worssam et al, 2022; Pan et al, 2020). We therefore, mapped chromatin accessibility changes using bulk ATAC-seq for SCA1+ and SCA1- lineage traced VSMCs. Overall design: We mapped chromatin accessibility changes using bulk ATAC-seq for SCA1+ and SCA1- lineage traced, EYFP+ VSMCs from injured animals separately, and compared these to EYFP+ VSMCs from littermate control animals that had not undergone surgery. In parallel, we also profiled EYFP-SCA1+ cells from injured animals.
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2025-03-17
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