Supplementary Material for Weiwei Zhao and Zhuo Fu, et al.Comprehensive analysis of the association between serum total cholesterol levels and cholelithiasis: A bidirectional Mendelian randomization study

Name: Supplementary Material for Weiwei Zhao and Zhuo Fu, et al.Comprehensive analysis of the association between serum total cholesterol levels and cholelithiasis: A bidirectional Mendelian randomization study
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doi.org2025-03-22 收录

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Supplementary Material for Weiwei Zhao and Zhuo Fu, et al.Comprehensive analysis of the association between serum total cholesterol levels and cholelithiasis: A bidirectional Mendelian randomization study Supplementary Table 1. Summary of the GWAS data for serum total cholesterol in this study Supplementary Table 2. Summary of the GWAS data for hypercholesterolemia in this study Supplementary Table 3. Table 3 Summary of the GWAS data for cholelithiasis in this study Supplementary Table 4. Genetic instruments (3-SNP - P5.0x10-8) for cholelithiasis from UK Biobank, TC from GLGC Supplementary Table 5. Genetic instruments (7-SNP - P5.0x10-8) for cholelithiasis from UK Biobank, TC from Metabolomics studies Supplementary Table 6. Genetic instruments (8-SNP - P5.0x10-8) for cholelithiasis from FinnGen , TC from GLGC Supplementary Table 7. Genetic instruments (11-SNP - P5.0x10-8) for Familial hypercholesterolemia from FinnGen, cholelithiasis from UK Biobank Supplementary Table 8. Genetic instruments (12-SNP - P5.0x10-8) for cholelithiasis from UK Biobank, Hypercholesterolemia from FinnGen Supplementary Table 9. Genetic instruments (14-SNP - P5.0x10-8) for cholelithiasis from UK Biobank , Familial hypercholesterolemia from finnGen Supplementary Table 10. Genetic instruments (15-SNP - P5.0x10-8) for cholelithiasis from FinnGen, TC from Metabolomics studies Supplementary Table 11. Genetic instruments (25-SNP - P5.0x10-8) for Hypercholesterolemia from FinnGen, cholelithiasis from UK Biobank Supplementary Table 12. Genetic instruments (34-SNP - P5.0x10-8) for cholelithiasis from FinnGen, TC from UK Biobank Supplementary Table 13. Genetic instruments (39-SNP - P5.0x10-8) for Hypercholesterolemia from UK Biobank , cholelithiasis from FinnGen Supplementary Table 14. Genetic instruments (41-SNP - P5.0x10-8) for TC from Metabolomics studies, cholelithiasis from FinnGen Supplementary Table 15. Genetic instruments (45-SNP - P5.0x10-8) for cholelithiasis from FinnGen, Hypercholesterolemia from UK Biobank Supplementary Table 16. Genetic instruments (47-SNP - P5.0x10-8) for TC from Metabolomics studies, cholelithiasis from UK Biobank Supplementary Table 17. Genetic instruments (56-SNP - P5.0x10-8) for male TC from UK Biobank , cholelithiasis from FinnGen Supplementary Table 18. Genetic instruments (68-SNP - P5.0x10-8) for TC from GLGC, cholelithiasis from FinnGen Supplementary Table 19. Genetic instruments (68-SNP - P5.0x10-8) for TC from GLGC, cholelithiasis from UK Biobank Supplementary Table 20. Genetic instruments (73-SNP - P5.0x10-8) for female TC from UK Biobank, cholelithiasis from FinnGen Supplementary Table 21. Genetic instruments (113-SNP - P5.0x10-8) for TC from UK Biobank, cholelithiasis from FinnGen

补充材料：赵伟伟、傅卓等人的血清总胆固醇水平与胆结石关联的全面分析：一项双向孟德尔随机化研究补充表 1：本研究中血清总胆固醇的 GWAS 数据概要补充表 2：本研究中高胆固醇血症的 GWAS 数据概要补充表 3：本研究中胆结石的 GWAS 数据概要补充表 4：来自 UK Biobank 的胆结石遗传工具（3-SNP - P5.0x10-8），TC 来自 GLGC 补充表 5：来自 UK Biobank 的胆结石遗传工具（7-SNP - P5.0x10-8），TC 来自代谢组学研究补充表 6：来自 FinnGen 的胆结石遗传工具（8-SNP - P5.0x10-8），TC 来自 GLGC 补充表 7：来自 FinnGen 的家族性高胆固醇血症遗传工具（11-SNP - P5.0x10-8），胆结石来自 UK Biobank 补充表 8：来自 UK Biobank 的胆结石遗传工具（12-SNP - P5.0x10-8），高胆固醇血症来自 FinnGen 补充表 9：来自 UK Biobank 的胆结石遗传工具（14-SNP - P5.0x10-8），家族性高胆固醇血症来自 finnGen 补充表 10：来自 FinnGen 的胆结石遗传工具（15-SNP - P5.0x10-8），TC 来自代谢组学研究补充表 11：来自 FinnGen 的高胆固醇血症遗传工具（25-SNP - P5.0x10-8），胆结石来自 UK Biobank 补充表 12：来自 FinnGen 的胆结石遗传工具（34-SNP - P5.0x10-8），TC 来自 UK Biobank 补充表 13：来自 UK Biobank 的高胆固醇血症遗传工具（39-SNP - P5.0x10-8），胆结石来自 FinnGen 补充表 14：来自代谢组学研究的 TC 遗传工具（41-SNP - P5.0x10-8），胆结石来自 FinnGen 补充表 15：来自 FinnGen 的胆结石遗传工具（45-SNP - P5.0x10-8），高胆固醇血症来自 UK Biobank 补充表 16：来自代谢组学研究的 TC 遗传工具（47-SNP - P5.0x10-8），胆结石来自 UK Biobank 补充表 17：来自 UK Biobank 的男性 TC 遗传工具（56-SNP - P5.0x10-8），胆结石来自 FinnGen 补充表 18：来自 GLGC 的 TC 遗传工具（68-SNP - P5.0x10-8），胆结石来自 FinnGen 补充表 19：来自 GLGC 的 TC 遗传工具（68-SNP - P5.0x10-8），胆结石来自 UK Biobank 补充表 20：来自 UK Biobank 的女性 TC 遗传工具（73-SNP - P5.0x10-8），胆结石来自 FinnGen 补充表 21：来自 UK Biobank 的 TC 遗传工具（113-SNP - P5.0x10-8），胆结石来自 FinnGen

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