BindingDB Entry 50006398: Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.

Small molecule binding data for protein 1,3-beta-glucan synthase component GLS2, 3-phosphoinositide dependent protein kinase-1, ALK tyrosine kinase receptor, Activator of S phase kinase DBF4/Cell division cycle 7-related protein kinase, Aurora kinase A/B, Aurora kinase A/Targeting protein for Xklp2, Axin-1/Glycogen synthase kinase-3 beta, BR serine/threonine-protein kinase 1, CAMK2B, CDK2/Bovine cyclin A, CaM kinase I alpha, CaM kinase II, CaM kinase IV, Calmodulin/Proto-oncogene tyrosine-protein kinase Src, Casein kinase I, Casein kinase I delta/epsilon, Casein kinase I isoform alpha, Casein kinase I isoform gamma-3, Cyclin-Dependent Kinase 5 (CDK5), Cyclin-dependent kinase 1, Death-associated protein kinase 3, Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase, Dual specificity protein kinase CLK1/CLK4, Dual specificity protein kinase CLK2, Dual specificity tyrosine-phosphorylation-regulated kinase 4, Dual-specificity tyrosine-phosphorylation regulated kinase 1A, Ephrin type-A receptor 2, Fibroblast growth factor receptor, Fibroblast growth factor receptor 3, Focal adhesion kinase 1/vascular endothelial growth factor receptor 3, Glycogen synthase kinase-3, Hepatocyte growth factor receptor, High affinity nerve growth factor receptor, Homeodomain-interacting protein kinase 2 (HIPK2), Homeodomain-interacting protein kinase 4, Insulin receptor, Insulin-like growth factor I receptor, Interleukin-1 receptor-associated kinase 1, Interleukin-1 receptor-associated kinase 4, JAK3/JAK1, JNK2/JNK3, MAP kinase-activated protein kinase 2, MAP kinase-activated protein kinase 3, MAP kinase-activated protein kinase 5, MAP kinase-interacting serine/threonine-protein kinase 1/2, MAP/microtubule affinity-regulating kinase 3, MER intracellular domain/EGFR extracellular domain chimera, Macrophage colony stimulating factor receptor, Mast/stem cell growth factor receptor Kit, Maternal embryonic leucine zipper kinase, Mitogen-activated protein kinase 12, Mitogen-activated protein kinase 8/9, Mitogen-activated protein kinase kinase kinase kinase 2, Mitogen-activated protein kinase kinase kinase kinase 4, Mitogen-activated protein kinase kinase kinase kinase 5, Mixed lineage kinase 7, Neurotrophic tyrosine kinase receptor, Non-receptor tyrosine-protein kinase TYK2, PAK 1/CDC42, PDZ-binding kinase, Phosphorylase kinase, Protein kinase C iota type/zeta type, Protein kinase C, PKC; classical/novel, Protein kinase N2, Proto-oncogene tyrosine-protein kinase ROS, Proto-oncogene tyrosine-protein kinase receptor Ret, RAC-alpha serine/threonine-protein kinase AKT1, Receptor protein-tyrosine kinase erbB-4, Receptor tyrosine-protein kinase erbB-2, Rho-associated protein kinase, Ribosomal protein S6 kinase, Ribosomal protein S6 kinase (P70S6K), Ribosomal protein S6 kinase alpha-1/alpha-3, SRC, Serine/threonine-protein kinase 17A, Serine/threonine-protein kinase 2, Serine/threonine-protein kinase AKT, Serine/threonine-protein kinase AKT2, Serine/threonine-protein kinase Chk1/2, Serine/threonine-protein kinase D2, Serine/threonine-protein kinase DCLK2, Serine/threonine-protein kinase MRCK-A, Serine/threonine-protein kinase MST2, Serine/threonine-protein kinase NEK2, Serine/threonine-protein kinase Nek4, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PLK1, Serine/threonine-protein kinase PLK3, Serine/threonine-protein kinase PLK4, Serine/threonine-protein kinase PRKX, Serine/threonine-protein kinase SRPK1, Serine/threonine-protein kinase Sgk1, Serine/threonine-protein kinase TAO2, Serine/threonine-protein kinase pim-1, Serine/threonine-protein kinase pim-2, Serine/threonine-protein kinase pim-3, Sphingosine 1-phosphate receptor, Sphingosine 1-phosphate receptor Edg-5/Sphingosine 1-phosphate receptor Edg-3, Testis-specific serine/threonine-protein kinase 1, Testis-specific serine/threonine-protein kinase 2, Tyrosine-protein kinase BTK, Tyrosine-protein kinase CTK, Tyrosine-protein kinase FER, Tyrosine-protein kinase FES, Tyrosine-protein kinase FRK, Tyrosine-protein kinase Fyn, Tyrosine-protein kinase ITK/TSK, Tyrosine-protein kinase JAK2, Tyrosine-protein kinase SYK, Tyrosine-protein kinase receptor FLT3, Tyrosine-protein kinase receptor TYRO3, Vascular endothelial growth factor receptor 1 and 2 (Flt-1 and KDR), Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2), and p38 delta/gamma, Uniprot A0A024QYW7, A0A024QZA8, A0A024R0J1, A0A024R0L5, A0A024R244, A0A024R2W7, A0A024R328, A0A024R567, A0A024R5P0, A0A024R5W3, A0A024R759, A0A024R7E4, A0A024R7M7, A0A024R7T2, A0A024RB77, A0A024RBU5, A0A024RC92, A0A024RD04, A0A024RD25, A0A090N7W4, A0A0S2Z3Y8, A0A140VJL1, A0A2P9DU05, A0A384MDW3, A0A384MR07, A0A384MTU6, A0ZT98, A0ZT99, A4D2J9, A8K7I0, B0LPE5, B0YIY3, F1T0G6, L7RSL3, O00141, O00311, O00444, O14757, O14965, O15264, O15530, O43293, O60674, O75116, O75582, O94806, O95819, O96013, O96017, P00533, P04626, P04629, P05129, P06213, P06239, P06241, P06493, P07332, P07333, P07948, P07949, P08069, P08581, P08922, P10721, P11309, P11362, P12931, P15735, P16591, P17948, P21453, P21802, P22455, P22607, P23443, P24941, P27448, P28482, P29317, P29597, P31749, P31751, P35916, P35968, P36888, P40989, P41743, P42679, P42685, P43405, P45983, P45984, P48729, P48730, P49137, P49760, P49840, P49841, P51451, P51617, P51812, P51817, P51955, P51957, P52333, P53350, P53778, P78368, Q00535, Q05513, Q05655, Q06187, Q06418, Q08881, Q12851, Q13153, Q13188, Q13464, Q13554, Q13555, Q13557, Q13627, Q14012, Q14680, Q15078, Q15303, Q16288, Q16513, Q16566, Q16620, Q16644, Q1HBJ4, Q548C2, Q5VT25, Q69FE3, Q6FI27, Q86V86, Q8IW41, Q8N568, Q8NE63, Q8TDC3, Q96GD4, Q96KB5, Q96PF2, Q96SB4, Q99500, Q9BXA7, Q9BZL6, Q9H228, Q9H2G2, Q9H2X6, Q9H3Y6, Q9H4B4, Q9HAZ1, Q9HBH9, Q9HCP0, Q9NR20, Q9NWZ3, Q9NYL2, Q9P1W9, Q9UBU7, Q9UEE5, Q9UL54, Q9UM73, Q9Y243, Q9Y4K4, Q9Y6M4, V9HWH0, W0S0X4, X5D2R1, and X5DNK3