Additional file 2 of Regulation of autoimmune arthritis by the SHP-1 tyrosine phosphatase

Additional file 2 Spleen cell populations of WT, Shp1-Tg+/+ and Shp1-Tg+/- mice. CD3+ cells are shown as % of lymphocytes. CD4+ and CD8+ cells are shown as % of CD3+ cells. Total B220+ cells are illustrated as the % of lymphocytes. Marginal zone, transitional 1, transitional 2 and follicular B cells are illustrated as % of B220+ cells. Plasma cells are seen as % of lymphocytes. Red color indicates statistically significant difference (n=4/group, Kruskal-Wallis test). B cell subpopulations were defined as: marginal zone: IgM high, CD21 high, CD23-; transitional 1: IgM high, CD21 low, CD23-; transitional 2: IgM high, CD21 med, CD23+; follicular: IgM low, CD21 med, CD23+; plasma cells: B220 low, CD19-, CD138+.