The key PK/PD parameters for %T>MIC to achieve different antibacterial effects.

NIAID Data Ecosystem2026-03-14 收录

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https://figshare.com/articles/dataset/The_key_PK_PD_parameters_for_T_MIC_to_achieve_different_antibacterial_effects_/21956149 数据链接链接失效反馈

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The key PK/PD parameters for %T>MIC to achieve different antibacterial effects.

创建时间：

2023-01-25

Petrov2018 - C-547 a 6-methyluracil derivative with long-lasting binding and rebinding on acetylcholinesterase

PK/PD建模

乙酰胆碱酯酶抑制剂

C-547, a candidate drug, is a potent slow-binding inhibitor of acetyl-cholinesterase, and the focus of this PK/PD model, which investigates the metabolism and clinical effect of C-547 when it is no lo

NIAID Data Ecosystem30

Parameter estimates of model Eq (24) obtained by fitting the time-kill data for BAA1705 and KP619 strains shown in Fig 2.

抗菌药效动力学

细菌时间-杀灭分析

Parameter estimates of model Eq (24) obtained by fitting the time-kill data for BAA1705 and KP619 strains shown in Fig 2.

Figshare2017-03-24 更新10

Resazurin-Based Time-Kill Assay In Acinetobacter Baumannii Ab074. Fluorescence Measurement Data For Excitation 544 Nm, Emission 590 Nm, Gain 1000.

抗菌药效动力学

时间-杀菌试验

There were 21 groups: 3 groups of transferrin alone in 3 different concentrations (1/3, 1, and 3 times of its MIC); 4 groups of antibiotics alone (ciprofloxacin and meropenem in 1/3 and 1 MIC concentr

Zenodo2020-09-18 更新00

Penicillin Pharmacodynamics in Four Experimental Pneumococcal Infection Models

抗菌药效动力学

动物感染模型

Clinical and animal studies indicate that with optimal dosing, penicillin may still be effective against penicillin-nonsusceptible pneumococci (PNSP). The present study examined whether the same strai

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Pharmacodynamic Modeling of Clarithromycin against Macrolide-Resistant [PCR-Positive mef(A) or erm(B)] Streptococcus pneumoniae Simulating Clinically Achievable Serum and Epithelial Lining Fluid Free-Drug Concentrations

抗菌药效动力学

细菌耐药性机制

The association between macrolide resistance mechanisms and clinical outcomes remains understudied. The present study, using an in vitro pharmacodynamic model, assessed clarithromycin (CLR) activity a

PubMed Central10

The key PK/PD parameters for %T>MIC to achieve different antibacterial effects.

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