Crystal structure of JAK3 with GCL258
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Crystal structure of JAK3 with GCL258 Descriptor: 1-phenylurea, 3-(3-cyclohexyl-3,8,10-triazatricyclo[7.3.0.0^{2,6}]dodeca-1,4,6,8,11-pentaen-5-yl)benzenesulfonyl fluoride, Tyrosine-protein kinase JAK3 Authors: Wang, G.Q, Chaikuad, A, Hillebrand, L, Gehringer, M, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2025-05-11 Release date: 2025-08-20 Last modified: 2025-10-22 Method: X-RAY DIFFRACTION (1.8 Å) Cite: A twist in the tale: shifting from covalent targeting of a tyrosine in JAK3 to a lysine in MK2. Rsc Med Chem, 16, 2025
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2025-05-11
