Analysis code and derived data for "Lipophilic versus hydrophilic statins in chronic subdural hematoma: an integrative network pharmacology, molecular docking, and Mendelian randomization study"

This deposit contains the analysis code, intermediate results, and publicationfigures for an in silico study that compared six statins (atorvastatin,rosuvastatin, simvastatin, pravastatin, pitavastatin, and fluvastatin) inchronic subdural hematoma using network pharmacology, molecular docking, anddrug-target Mendelian randomization. All inputs are public databases: Comparative Toxicogenomics Database, ChEMBL,KEGG, Gene Ontology, STRING, PubChem, Protein Data Bank, OpenGWAS (LDLcholesterol ieu-b-110), and FinnGen R12. No new patient-level data werecollected, and no additional ethics approval was required. To reproduce, run the numbered scripts (01-42) in order from the project root.Scripts 04-08, 11-14, 19-21, and 23 require network access; the Mendelianrandomization scripts require an OpenGWAS API token supplied via theOPENGWAS_TOKEN environment variable. The docking pipeline (scripts 15-17)requires AutoDock 4.2.6 and MGLTools 1.5.7. Software environment: R 4.3.1 (TwoSampleMR 0.7.13, ieugwasr 1.2.0, MRPRESSO1.0, clusterProfiler 4.8.3, org.Hs.eg.db 3.17.0) and Python 3.7.