Identification of gene signature in human colorectal CD44+ cancer stem cells. Homo sapiens

We prospectively isolated human colorectal CD44+ cancer stem cells (CSCs) from organoids and primary colorectal cancer. The gene expression of CD44+ CSCs are relevant to each other between organoids and primary tissues. The common gene signature in two different modality identifies CSCs' properties with the biological significance shown in original article. Overall design: Gene expression profiles of primary colorectal cancer cells and organoids, which were purified into CD44- and CD44+ fraction by cell sorting, were analyzed.