DATA.pdf

Data are in PDF format. This study focused on the cognitive function of women with type 1 diabetes in pregnancy. We investigated risk factors for a low cognitive score as age, duration of Diabetes, BMI, subclinical hypothyroidism, cardiovascular autonomic neuropathy, the impact of hypo-/hyperglycemia, and C-peptide preservation. Material and methods. Seventy-eight pregnant women with type 1 diabetes (age 31.1±5.4 years, diabetes duration 14.3±8.9 years) were included in the study. Cognitive function was assessed in different domains, such as reasoning, memory, attention, coordination, and perception. Results. The cognitive test values ≥400 were considered high scores, and values <400 were considered low. Relative risks for low scores for general cognitive function are associated with increased BMI >25 kg/m2 2.208 (95% CI 1.116-4.370), HbA1c >6.5% RR 0.774 (95% CI 0.366-1.638), subclinical hypothyroidism RR 3.111 (95% CI 1.140-8.491), impaired cardiovascular autonomic neuropathy RR 2.250 (95% CI 1.000-5.062) CGM glucose values >7.8 RR 1.875 (95% CI 0.757-4.642), and CGM glucose values <3.9 RR 0.938 (95% CI 0.346-2.539). In women with C-peptide preservation in 1st trimester RR 0.297 (95% CI 0.097-0.912, p=0.034). Conclusion. BMI >25 kg/m2, subclinical hypothyroidism, and cardiovascular autonomic neuropathy are associated with increased risk and postprandial C-peptide preservation with reduced risk for cognitive impairment in pregnant women with type 1 diabetes.