Impact of CDK7 inhibition across a range of inhibitors in the context of heat shock

Here we evaluate the effect of CDK7 inhibition in the context of heat shock across three distinct inhibitors. Two inhibitors are Syros compounds SY-5609 and SY-5102. The final inhibitor is 3MBPP1 in a CDK7 analog sensitive cell line. We find that overall the same gene programs are impacted. RNA-seq in OV90 cells to evaluate the effects of CDK7 inhibition under HS stimulated conditions. There are 3 biological replicates for each condition. Inhibitors here include SY-5102 and 3MBPP1 (in an OV90 CDK7-analog sensitive cell line).