Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.
收藏PubMed Central1991-03-01 更新2026-05-16 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC51097/
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资源简介：
Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ProTGF-alpha is cleaved at a slow rate and accumulates on the cell surface, thereby mediating cell-cell adhesion and mitogenic stimulation. We show here that cleavage of membrane proTGF-alpha by an elastase-like enzyme constitutes an important regulatory step in the generation of soluble TGF-alpha. Cleavage is activated in response to serum factors and tumor-promoting phorbol esters, leading to depletion of cell surface proTGF-alpha, which disperses as soluble factor. Activation of proTGF-alpha cleavage is mediated by protein kinase C-dependent and -independent mechanisms. The results demonstrate the existence of mechanisms that control the switch of TGF-alpha from a juxtacrine to a paracrine growth factor. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1991-03-01
