P. falciparum genes absent in P. vivax with possible role in human virulence.

Selected subset of identified chromosome-internal genes present in the highly virulent human parasite P. falciparum but absent in the less virulent human parasite P. vivax. Potential virulence-associated function of these genes is predicted based on characteristics shared with known virulence factors, including the presence of a PEXEL motif, signal peptides, and transmembrane domains, or is predicted based on co-expression and protein interaction data [35], [38]. Genes ordered and grouped by similarity of their IDC expression profile (see legend Table 1). A table with graphical RNA-seq expression profiles for these genes is provided in Table S11. Abbreviations: OG: closest OrthoMCL DB species out-group with predicted ortholog of this gene; PLASM: Plasmodium; ALVE: Alveolates; PROT: Proteobacteria; SZ: sporozoites; (el)GC: (early/late) gametocytes; TZ: trophozoite; MZ: merozoites; SC: schizont; iRBCm: infected red blood cell membrane (PIESPs)/Schizont; RU: erythrocyte rupture; OPI: ontology-based pattern identification; TM: predicted transmembrane; SP: predicted signal peptide; PX: PEXEL export motif. ¥ PF14_0708 has a predicted OrthoMCL DB ortholog in P. vivax (PVX_123110), but is present as extra copy in P. falciparum.