Single-cell RNA sequencing of murine tumor-susceptible germ cells
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
In response to signals from the embryonic testis, germ cell intrinsic factor NANOS2 coordinates a sex-specific transcriptional program necessary for differentiation of pluripotent-like primordial germ cells toward a unipotent spermatogonial stem cell fate. Emerging evidence indicates that genetic risk factors contribute to testicular germ cell tumor initiation by disrupting sex-specific differentiation. Here, using a mouse model of spontaneous testicular teratomas, we report that a subpopulation of germ cells failing to express NANOS2 is enriched for developmental phenotypes required for tumorigenesis. We demonstrate that only in the absence of NANOS2 do germ cells have a transcriptional profile enriched for Myc signaling and primed pluripotency and transform into embryonal carcinoma cells. We conclude that NANOS2 is the nexus through which many genetic risk factors exert their influence on tumor susceptibility. We propose that NODAL signaling, which is present in the developing testis, drives germ cell transformation in the absence of sex specification.
提供机构：
Baylor College of Medicine
创建时间：
2022-02-20
