Sister Mary Joseph's Nodule in Fallopian Tube Cancer: Exploring the Metastatic Pathway

Three possible metastatic pathways forSister Mary Joseph's nodule (SMJN) have been postulated: hematogenous spread, lymphatic dissemination, and direct invasion. However, detailed analyses of these metastatic pathways, particularly using gene expression profiling, remain notably absent from the literature. we investigated the metastatic patterns of SMJN by performing RNA microarray analysis on the primary tumor and each metastatic site in a case of fallopian tube cancer presenting with SMJN and inguinal lymph node metastasis. We collected tumor tissue samples from the primary lesion, umbilical metastasis, and inguinal lymph node metastasis for RNA microarray analysis.