Spatiotemporal dysregulation of neuron-glia related genes and pro-/anti-inflammatory miRNAs in the 5xFAD mouse model of Alzheimer's disease - Supplementary data

Supplementary Table 1.  Expression profile of the genes that revealed no significant differences in the prefrontal cortex (PFC) and the hippocampus (HPC) of the 5xFAD mice, at 6- and 9-month-old, assessed by RT-qPCR. Results are average ± SEM analysed by three-way ANOVA (α = 0.05) with Šídák's multiple comparisons test for the factors: Age (6 vs. 9 months), Genotype (WT vs. 5xFAD) and Region (hippocampus vs. prefrontal cortex). 

Supplementary Table 2.  miRNA-target table for the Analyzed microRNAs and targets selected for this study. Obtained in the online platform https://www.mirnet.ca/

Supplementary Table 3.  Node table for the analyzed microRNAs and targets selected for this study. We only considered miRNAs and/or targets with a node degree of at least 2. Obtained in the online platform https://www.mirnet.ca/

Supplementary Table 4.  Bivariate Pearson’s correlation coefficients and respective p-values obtained between all miRNAs and genes.

Supplementary Table 5.   List of microRNAs analyzed by RT-qPCR and their primer sequences.

Supplementary Table 6.  List of genes and respective primer sequences used for mRNA analysis by RT-qPCR.

Supplementary Table 7.  Raw data used for correlational analysis in hippocampus (HPC) and prefrontal cortex (PFC) using the corrplot package in RStudio software.