Replication Data for: The effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model

This is a data of the study "The effect of pralidoxime on coronary perfusion pressure during cardiopulmonary resuscitation in a pig model". we investigated the effects of pralidoxime administration during cardiopulmonary resuscitation (CPR) in a pig model, with a focus on ischemic contracture and coronary perfusion pressure (CPP). After 14 minutes of untreated ventricular fibrillation, followed by 8 minutes of basic life support, 16 pigs randomly received either 80 mg/kg of pralidoxime (pralidoxime group) or an equivalent volume of saline (control group) during advanced cardiovascular life support (ACLS). Mixed-model analyses of left ventricular (LV) wall thickness and LV chamber area during ACLS revealed no significant group effects or group-time interactions, whereas a mixed-model analysis of the CPP during ACLS revealed significant group effect (P = 0.038) and group time interaction (P <0.001). Post-hoc analyses revealed significant increases in CPP in the pralidoxime group, starting at 5 minutes after pralidoxime administration. No animal, except one animal in the pralidoxime group, achieved ROSC; thus, the rate of ROSC did not differ between the two groups.