pgc-substance-use

# PGC Substance Use Disorders — GWAS Summary Statistics [](https://creativecommons.org/licenses/by/4.0/) ## Dataset Description Genome-wide association study (GWAS) summary statistics for **Substance Use Disorders** phenotypes from the [Psychiatric Genomics Consortium (PGC)](https://pgc.unc.edu/). This dataset contains multiple GWAS publications as separate subsets (configs). Each can be loaded independently. ## Usage ```python from datasets import load_dataset # Load a specific GWAS (e.g., SUD2023) ds = load_dataset("OpenMed/pgc-substance-use", "SUD2023") print(ds) ``` ### Available Configs ```python from datasets import get_dataset_config_names configs = get_dataset_config_names("OpenMed/pgc-substance-use") print(configs) ``` ## Subsets (Publications) | Config | Phenotype | Journal | Year | PubMed | Rows | License | |--------|-----------|---------|------|--------|------|---------| | `SUD2023` | Substance Use Disorder | Nature Mental Health | 2023 | [37250466](https://pubmed.ncbi.nlm.nih.gov/37250466/) | 5,736,488 | CC BY 4.0 | | `sud2018-alc` | Alcohol Dependence | Nature Neuroscience | 2018 | [30482948](https://pubmed.ncbi.nlm.nih.gov/30482948/) | — | CC BY 4.0 | | `sud2019-alcuse` | Alcohol Use / AUDIT | American Journal of Psychiatry | 2019 | [30336701](https://pubmed.ncbi.nlm.nih.gov/30336701/) | — | CC BY 4.0 | | `sud2020-cud` | Cannabis Use Disorder | Lancet Psychiatry | 2020 | [33096046](https://pubmed.ncbi.nlm.nih.gov/33096046/) | — | CC BY 4.0 | | `sud2020-op` | Opioid Dependence | Molecular Psychiatry | 2020 | [32099098](https://pubmed.ncbi.nlm.nih.gov/32099098/) | 57,445,238 | CC BY 4.0 | ## Data Format All data has been converted to **Apache Parquet** format with shards of 10,000 rows. Common columns include: | Column | Description | |--------|-------------| | `SNP` / `ID` | SNP rsID or variant identifier | | `CHR` | Chromosome | | `BP` / `POS` | Base-pair position (typically GRCh37/hg19) | | `A1` / `ALT` | Effect allele | | `A2` / `REF` | Non-effect (reference) allele | | `OR` / `BETA` | Odds ratio or effect size | | `SE` | Standard error | | `P` | P-value | | `INFO` | Imputation quality score | | `FRQ` / `MAF` | Allele frequency | | `_source_file` | Original source filename | > **Note:** Column names vary between publications. The `_source_file` column tracks the original file each row came from. ## Citation When using any subset, please cite: 1. The **original publication** (see PubMed links above) 2. The **data DOI** from Figshare (see supplementary metadata) 3. **Acknowledge the PGC:** > "Data were obtained from the Psychiatric Genomics Consortium — https://pgc.unc.edu/" ## Terms of Use This dataset is released under the **[CC BY 4.0](https://creativecommons.org/licenses/by/4.0/)** license. By using PGC summary statistics you agree to: 1. Cite the original publication(s) 2. Not attempt to re-identify individual participants 3. Comply with the PGC's [data use policies](https://pgc.unc.edu/for-researchers/data-access/) ## Source - **Consortium:** [Psychiatric Genomics Consortium (PGC)](https://pgc.unc.edu/) - **PGC Downloads:** [pgc.unc.edu/for-researchers/download-results/](https://pgc.unc.edu/for-researchers/download-results/) --- *Last updated: April 2026*