CBL binds VAV

Cbl and Vav interact in thymocytes and peripheral T cells (Marengere et al. 1997). Cbl phosphorylated at Y700 binds Vav1 in 293T cells, leading to Vav ubiquitinylation and proteolytic degradation.

Cbl与Vav在胸腺细胞和周围T细胞中相互作用（Marengere等，1997年）。在293T细胞中，Cbl在Y700位点的磷酸化与Vav1结合，导致Vav发生泛素化和蛋白水解降解。