The A-helix epitope targeted by the A06 antibody is highly conserved across numerous types of influenza.

A-helix epitope sequences from novel H1N1, current and past seasonal isolates of H1N1, H5N1 and avian H9N2 hemagglutinin proteins were aligned. Positions are labeled according to HA2 numbering. Amino acids at positions 19-21, 41, 42, 45, 46, 49, 52, 53 and 56 are antibody contact points [13], [17]. The column on the far right indicates in vitro microneutralization minimal inhibitory concentrations (MIC) of antibody A06 in µg/ml for the isolates tested (ND = not done, * = previously reported data [8]).