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The study aims to analyse key determinants of urban and peri-urban youth employment in agribusiness in Malawi to support youth policies. A mixed-methods approach is used, which combines both quantitative and qualitative analyses. The quantitative method involved a Bivariate Logit Model and Multinomial Logit Model to analyse nationally representative survey data from the Fourth Integrated Household Survey in 2016–2017. The qualitative method employed thematic analysis to data generated through Focus Group Discussions and Key Informant Interviews for key stakeholders involved in agri-business in Lilongwe district. The qualitative analysis, which focuses on a case study for urban and peri-urban youth in agribusiness, was used to validate, and provide context for the quantitative analysis. The results revealed that a majority of the urban and peri-urban youth engaged in agribusiness across Malawi work in sole farming (family farms or ganyu); in addition, women outnumber men in terms of engagement in agribusiness, and this stems from tradition. In addition, the determinants that affect youth’s engagement in agribusiness consist of demographic factors, institutional support, assets, and shocks. It was also shown that men were more likely than women to be engaged in sole farming, but they were as likely as women to be engaged in other forms of agribusiness. The policy recommendation from this study is that programs aimed at supporting youth engagement in agribusiness should consider a variety of factors; If resources are limited, the programs should ensure that they offer capacity strengthening for the youth in the form of extension services and practical training in agribusiness.