Transcription landscape of adipose tissue changes in response to telomerase knockout in mesenchymal progenitors. Transcription landscape of adipose tissue changes in response to telomerase knockout in mesenchymal progenitors

We generated mice with telomerase (TERT) gene knock-out (KO) that undergo premature telomere shortening in adipose stromal cells expressing Pdgfra or Pdgfrb. Stromal vascular cells were isolated from inguinal adipose tissue of Pdgfra-Cre; TERT fl/fl mice (Sample name A_SAT), Pdgfrb-Cre; TERT fl/fl mice (Sample name KO_SAT), and of control TERT WT mice (Sample name PBS_SAT). Overall design: scRNAseq analysis of subcutaneous adipose tissue stromal vascular cells was performed.