Vaccine efficacy at the signature sites in the non-vaccine proteins.

1HXB2 numbering2The sieve effect was detected for the CRF01_AE consensus sequence. The corresponding vaccine amino acids are given after the colon. They are in parentheses if the effect was “vMismatch” (with greater divergence from the vaccine AA among placebo recipients).3Symmetrized estimated vaccine efficacies (for hazard ratio (HR) above 1, symmetrized VE = [1 − hazard ratio (HR)]×100%; for HR below 1, symmetrized VE = − [1 − (1/(HR))]×100%) to prevent infection with specific HIV-1 genotypes.4The p-values for Env 777 and Pol 497 were not calculable for the DVE method because one of the treatment groups (the vaccine-recipient group) exhibited no variation at these sites.Vaccine efficacy at the signature sites in the non-vaccine proteins.