Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health status (TRIUMPH)

The Translational Research Investigating Underlying disparities in acute Myocardial infarction Patients' Health status (TRIUMPH) cohort is a cohort of 4340 patients prospectively enrolled after hospitalization for acute myocardial infarction (AMI) between June 1, 2005, and December 31, 2008 from 24 U.S. hospitals. Consenting patients had detailed chart abstractions of their medical history and processes of inpatient care, supplemented with a detailed baseline interview. Detailed genetic and metabolic data were obtained at hospital discharge in 2979 (69%) and 3013 patients (69%), respectively. Centralized follow-up interviews sought to quantify patients' post-discharge care and outcomes, with a focus on their health status (symptoms, function, and quality of life). Reprinted from [Article Citation], with permission from [Publisher]. ]]> The goal of TRIUMPH was to recruit a consecutive cohort of AMI patients from each enrolling center. For sites with large volumes of MI patients, a systematic sampling strategy (e.g. screening every second or every third MI case based on the time of the first positive cardiac enzyme blood test and not convenience) was performed. Only patients with a Type 1 AMI (i.e. spontaneous MI related to ischemia due to a primary coronary event) were eligible for enrollment. Patients had to fulfill the following criteria for eligibility: (1) >=18 years, (2) elevated troponin level (cardiac enzyme elevation as a complication of elective coronary revascularization did not qualify), (3) clinical features of ischemia (e.g. prolonged ischemic signs/symptoms, electrocardiographic ST changes in >=2 consecutive leads), and (4) initial presentation to the enrolling institution or transfer within the first 24 hours of original presentation. This latter criterion ensured that the primary clinical decision making was conducted at the enrolling site. Incarcerated patients were not eligible, and all patients signed an informed consent that was approved by each institution.]]>