PreDREM

PreDREM is a database of DNA regulatory motifs and motifs modules predicted from DNase I hypersensitive sites in 349 human cell and tissue samples. It contains 845-1325 predicted motifs in each sample, which result in a total of 2684 non-redundant motifs. In comparison with seven large collections of known motifs, more than 84% of the 2684 predicted motifs are similar to the known motifs, and 54-76% of the known motifs are similar to the predicted motifs. PreDREM also stores 43 663-20 13 288 motif modules in each sample, which provide the cofactor motifs of each predicted motif.PreDREM是一款收录DNA调控基序（DNA regulatory motifs）与基序模块的数据库，其数据均源自对349个人类细胞和组织样本的DNase I超敏感位点（DNase I hypersensitive sites）的预测分析。每个样本中包含845至1325个预测基序，总计得到2684个非冗余基序（non-redundant motifs）。与七大类已知基序集合相比，2684个预测基序中有逾84%与已知基序具有相似性，且54%至76%的已知基序可与预测基序匹配。PreDREM还在每个样本中存储了43663至2013288个基序模块，这类模块可为每个预测基序提供其所对应的辅因子基序（cofactor motifs）。

搜集汇总

背景与挑战

背景概述

PreDREM是一个基于349个人类细胞和组织样本中DNase I超敏感位点预测的DNA调控基序及基序模块数据库。该数据库包含2684个非冗余预测基序，其中超过84%与已知基序相似，并提供了大量样本特异的基序模块信息。