Analysis of VYD2311-Resistant Residues in SARS-CoV-2 Genome Submissions (Non-INSDC, n = 19,792, 2024 Samples)

This dataset summarizes a large-scale in silico screening of 19,792 SARS-CoV-2 genomes from Chinese sources, focused on VYD2311 monoclonal antibody escape-associated mutations within the spike protein receptor-binding domain. The analysis identified 13 unique escape mutations, with prevalent substitutions at S417T, S501T, S446A, S444T, and S500T, representing potential evolutionary drift at key neutralizing epitopes in 2024. The dataset includes detailed mutation profiles, resistant sequence listings, and a resistance frequency panel plot, supporting future comparative or temporal studies of spike mutation dynamics. Data processed by [e-mail]