THE UNRESOLVED STRUGGLE OF 16S MICROBIAL PROFILING, A BENCHMARKING ANALYSIS OF CLUSTERING AND DENOISING METHODS.

Here we trying to find with complex mock using 16S rRNA gene sequencing an answer of which is better regrading denoising or clustering methods in 16S rRNA Analysis. we unified preprocessing steps in most of tools and made our analysis trying to derive a fair comparison accross 8 common tools.