Crystal structure of human KRAS G12C covalently bound with AstraZeneca WO2020/178282A1 compound 76
收藏Protein Data Bank Japan2024-10-16 更新2026-06-30 收录
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Crystal structure of human KRAS G12C covalently bound with AstraZeneca WO2020/178282A1 compound 76 Descriptor: 1-[(5S,9P,12aR)-9-(2-chloro-6-hydroxyphenyl)-8-ethynyl-10-fluoro-3,4,12,12a-tetrahydro-6H-pyrazino[2,1-c][1,4]benzoxazepin-2(1H)-yl]propan-1-one, GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, ... Authors: Mohr, C. Deposit date: 2022-07-11 Release date: 2022-08-17 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.81 Å) Cite: Modeling receptor flexibility in the structure-based design of KRAS G12C inhibitors. J.Comput.Aided Mol.Des., 36, 2022
创建时间：
2022-07-11
