The role of GCNT1 mediated O-glycosylation in aggressive prostate cancer.

To identify signalling pathways altered by GCNT1 in prostate cancer cells, we established PC3 stable cell lines in which GCNT1 was overexpressed. We then performed differential gene expression, Gene Ontology and GSEA analyses using data obtained from RNA-seq of the control and OE cell lines. Overall design: Comparative gene expression profiling analysis of RNA-seq data for Lenti-ORF negative control PC3 cells vs PC3 cells with GCNT1 overexpression.